Website design and online tool development *These authors contributed equally to this work. (2017) GRcalculator: an online tool for calculating and mining dose-response data. Clark N*, Hafner M*, Kouril M, Williams EH, Muhlich J, Pilarczyk M, Niepel M, Sorger PK, Medvedovic M. (2017) Alternative drug sensitivity metrics improve preclinical cancer pharmacogenomics. (2016) Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs. Hafner M*, Niepel M*, Chung M, Sorger PK. All of the web applications are implemented in R, using the Shiny framework for interactive applications.įor offline computation, analysis, and visualization, see the Bioconductor R package GRmetrics. The former (HMS) is one of the LINCS Data and Signature Generation Centers (DSGCs) and the latter (Cincinnati) is part of the BD2K-LINCS Data Coordination and Integration Center (DCIC). This web application was developed as part of the NIH LINCS Consortium in a collaboration between Harvard Medical School's Sorger Lab and Laboratory of Systems Pharmacology (LSP) and the University of Cincinnati's Laboratory for Statistical Genomics and Systems Biology.
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